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<div data-server-rendered="true" id="__nuxt"><!----><div id="__layout"><div class="h-screen flex flex-col"><div class="top"></div> <header role="banner" class="mb-4"><div class="flex max-sm:flex-col container"><a href="/" class="flex-1 max-sm:hidden nuxt-link-active"><div class="pt-6"><img src="/images/expasy-addon.png" srcset="/images/expasy-addon.png, /images/expasy-addon@2x.png 2x" alt="Expasy: Swiss Bioinformatics Resource Portal" class="inline-block"></div></a> <nav role="navigation" class="max-sm:w-full"><ul class="nav"><li class="inline-block"><a href="/" class="nav__link nuxt-link-active"> Home </a></li> <li class="inline-block"><a href="/about" class="nav__link"> About </a></li> <li class="inline-block"><a href="https://www.sib.swiss/about/news" target="_blank" rel="noopener noreferer" class="nav__link">
SIB News
</a></li> <li class="inline-block"><a href="/contact" class="nav__link"> Contact </a></li></ul></nav></div></header> <main role="main" class="page-main flex-grow"><div class="container container--xs"><form action="/search" method="get" class="search"><div class="text-center"><img src="/images/expasy-homepage.png" srcset="/images/expasy-homepage.png, /images/expasy-homepage@2x.png 2x" alt="Expasy: Swiss Bioinformatics Resource Portal" class="mb-8 inline-block md:hidden"></div> <div class="flex mb-1"><label for="search" class="inline-block h4 mb-2 sr-only">
Explore high-quality biological data resources
</label> <input id="search" name="search" type="search" required="required" class="field search__input"> <button type="submit" class="btn search__submit"><svg aria-hidden="true" focusable="false" role="img" class="icon icon--search icon--150"><!----> <use xlink:href="/_nuxt/img/icons.2l2yMrcx.svg#search"></use></svg></button></div> <div class="text-sm">
e.g.
<a href="/search/blast">BLAST</a>,
<a href="/search/uniprot">UniProt</a>,
<a href="/search/msh6">MSH6</a>,
<a href="/search/albumin">Albumin</a>...
</div> <!----></form></div> <div class="container container--md"><section class="py-5 border-neutral-200 border-t"><div class="rich-text"><h1>neXtProt</h1> <p>
Established in 2010, the neXtProt knowledgebase was created to capture insights from emerging omics studies by
performing deep curation of clinically relevant disease mutations. It employed cutting-edge semantic
technologies to integrate data from genomics, transcriptomics, and proteomics.
</p> <p>
Additionally, neXtProt developed advanced tools to facilitate the exploration and querying of this data,
making it accessible to both general and specialized protein research. Between 2011 and 2023, it was
recognized as the primary reference resource for the Human Proteome Project (HPP). These achievements made
neXtProt a powerful tool for advancing our understanding of the human proteome and its implications in health
and disease.
</p> <p><strong>After 14 years, neXtProt has reached its end of life and no longer provides data or services. Thank you for
your support and trust!</strong></p> <p>
Though neXtProt services have ended, we’ve ensured that its data and tools remain accessible for future
research.
</p> <h2 style="margin-bottom:1em;">Accessing Archived neXtProt Data and Source Code</h2> <p><strong>Retrieve Data on Zenodo</strong></p> <ul style="margin-left:2em;"><li><a href="https://doi.org/10.5281/zenodo.14163587" target="_blank">DOI 10.5281/zenodo.14163587</a>: Latest
release (September 2023) with extensive metadata.
</li> <li><a href="https://zenodo.org/communities/sib-biodata-resources/" target="_blank">
SIB Swiss Institute of Bioinformatics - Biodata Resources Zenodo community</a>: neXtProt data releases prior to September 2023.
</li> <li><a href="https://doi.org/10.5281/zenodo.14355521" target="_blank">DOI 10.5281/zenodo.14355521</a>: neXtProt
functional proteome project .
</li> <li><a href="https://doi.org/10.5281/zenodo.14355851" target="_blank">DOI 10.5281/zenodo.14355851</a>: Protein
kinase function portal.
</li> <li><a href="https://doi.org/10.5281/zenodo.14356028" target="_blank">DOI 10.5281/zenodo.14356028</a>: Cancer
variants portal.
</li> <li><a href="https://doi.org/10.5281/zenodo.14356359" target="_blank">DOI 10.5281/zenodo.14356359</a>; Ion
channels variants portal.
</li></ul> <p><strong>Explore Source Code on GitHub</strong></p> <ul style="margin-left:2em;"><li><a href="https://github.com/calipho-sib" target="_blank">Main repository</a>: Comprehensive neXtProt
projects and resources.
</li> <li><a href="https://github.com/calipho-sib/feature-viewer" target="_blank">Feature Viewer</a>: Interactive
protein feature visualization tool.
</li></ul> <h2 style="margin-bottom:1em;">References</h2> <ul style="margin-left:2em;"><li>
Zahn-Zabal M, Michel PA, Gateau A, Nikitin F, Schaeffer M, Audot E, Gaudet P, Duek PD, Teixeira D, Rech de
Laval V, Samarasinghe K, Bairoch A, Lane L. The neXtProt knowledgebase in 2020: data, tools and usability
improvements. Nucleic Acids Res. 2020 Jan 8;48(D1):D328-D334. doi:
<a href="https://doi.org/10.1093/nar/gkz995" target="_blank">10.1093/nar/gkz995</a>. PMID:
<a href="https://pubmed.ncbi.nlm.nih.gov/31724716/" target="_blank">31724716</a> PMCID:
<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7145669/" target="_blank">PMC7145669</a></li> <li>
Adhikari S, Nice EC, Deutsch EW, Lane L, et al. A high-stringency blueprint of the human proteome. Nat
Commun. 2020 Oct 16;11(1):5301. doi:
<a href="https://doi.org/10.1038/s41467-020-19045-9" target="_blank">10.1038/s41467-020-19045-9</a>.
</li> <li>
Paladin L, Schaeffer M, Gaudet P, Zahn-Zabal M, Michel PA, Piovesan D, Tosatto SCE, Bairoch A. The
Feature-Viewer: a visualization tool for positional annotations on a sequence. Bioinformatics. 2020 May
1;36(10):3244-3245. doi:
<a href="https://doi.org/10.1093/bioinformatics/btaa055" target="_blank">10.1093/bioinformatics/btaa055</a>.
PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31985787/" target="_blank">31985787</a>.
</li></ul> <h2>Looking for human protein information?</h2> <p>Please refer to:</p> <ul style="margin-left:2em;"><li><a href="https://www.uniprot.org/uniprotkb?query=Human&facets=model_organism%3A9606%2Creviewed%3Atrue" target="_blank">human reviewed (Swiss-Prot) data</a>
in UniProt
</li> <li><a href="https://hppportal.net/" target="_blank">HPP Portal</a>, a knowledge hub to support the HPP Grand
Challenge
</li></ul></div>…
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